进驻高原不同海拔高度不同时间健康青年血脂与载脂蛋白的变化

GHANGES OF BLOOD—LIPID AND APO IN HEALTHY YOUNG ADULTS UNDER VARIOUS ALTITUDE CONDITION

目的：探讨不同海拔高度不同居住高原时间健康人脂质代谢状况；方法：对从平原进驻海拔３７００ｍ和５３８０ｍ高原第７天和半年的某部官兵血清胆固醇（Ｃｈ），甘油三酯（ＴＧ），高密度脂蛋白（ＨＤＬ—Ｃ），低密度脂蛋白（ＬＤＬ—Ｃ）及载脂蛋白Ａ—１（ＡｐｏＡ—１），载脂蛋白Ｂ（ＡｐｏＢ）进行检测，并与海拔１４００ｍ健康青年作对照。结果：初入高原Ｃｈ、ＴＧ明显高于平原（Ｐ＜０．０５或Ｐ＜０．０１），且随海拔高度的升高而增高（Ｐ＜０．０１），居住时间的延长而降低（Ｐ＜０．０５或Ｐ＜０．０１）。ＨＤＬ—Ｃ和ＬＤＬ—Ｃ在海拔３７００ｍ居住半年及５３８０ｍ居住第７天和半年均较平原降低显著（Ｐ＜０．０５或Ｐ＜０．０１），ＬＤＬ—Ｃ随居住时间的延长，海拔高度的升高而降低（Ｐ＜０．０１）。ＨＤＬ—Ｃ变化无显著性差异（Ｐ＜０．０５）。ＡｐｏＡ—１在进驻５３８０ｍ第７天和半年明显低于平原（Ｐ＜０．０５或Ｐ＜０．０１），且随居住时间的延长而增高（Ｐ＜０．０５）；ＡｐｏＢ在５３８０ｍ居住半年明显高于第７天及海拔１４００ｍ（Ｐ＜０．０５）。结论：高原地区缺氧引起脂质代谢加强，这可能是机体对维持细胞和组织的能量供给的一种应激性反应。

Objective:To explore the significance of the changes of blood-lipid and Apo in healthy young adults under various altitude condition for different exposed-times.Methods:level of Ch,TG,HDL-C,LDL-C and Apo(Apo A-1,Apo B) in serum were examined in healthy officers and soldiers(male,mean age 19 6 year-old)who ascended to altitude of 3 700 m and 5 380m from 1 400m on 7th day and after 6 postaltitude months and compared with that at 1 400m altitude.Results:(1)the level of Ch and TG were remarkably higher on the 7th postaltitude day than before exposure to altitude( P <0 05 or 0 01)and increased with elevating altitude( P <0 01;in contrast;were decreased with prolong exposed-time( P <0 05 or <0 01).(2)the level of HDL-C and LDL-C were decreased at 5 380m altitude on the 7th day and for 6 months and after postaltitude(3 700m) 6 months ( P <0 05 or <0 01),and lower LDL-C with higher altitude and longer exposed-time( P <0 01),but HDL-C had no a great changes( P >0 05).(3)Level of ApoA-1 was lower on 7th postaltitude day and for 6 months at 5 380m altitude than at plain(1 400m),but was increased followed longer exposed-time( P <0 05).(4)the level of Apo B was higher after the 6 months postaltitude(5 300m) than that on 7th day and at plain.Conclusion:under high altitude environment,that the metabolism of the lipid is strengthened in healthy young adults could be a stress reaction to maintain energy of human.