自体血照射回输提高食管癌患者抗辐射的作用

Radioprotection of radiated auto blood transfusion on patients with esophageal carcinoma *

目的探讨自体血液照射回输提高食管癌患者抗辐射能力及对机体正常组织的合理防护．方法食管癌患者６６例随机分为研究组（自体血液照射回输加放疗）和对照组（常规放疗组）．观察两组急性放射性食管炎的发生率及研究组患者血疗前后ＩＬ２，Ｔ淋巴细胞亚群的变化．结果急性放射性食管炎发生率：研究组为１２１％（４／３３），对照组６０６％（２０／３３，Ｐ＜００１）；发生急性放射性食管炎的平均放疗剂量（Ｘ±ＳｃＧＹ）研究组４０５０±８２２，对照组２４６０±６０９（Ｐ＜００１）；研究组血疗前后ＩＬ２，Ｔ淋巴细胞亚群也都有非常显著变化．结论自体血液照射回输可提高食管癌患者抗辐射功能，可能是低剂量辐射刺激诱发机体的适应性和刺激机体的免疫功能，提高了正常组织对放疗的耐受量而不对肿瘤组织起保护作用．

AIM To investigate the protective effect of radiated auto blood transfusion on radiation. METHODS Sixty six cases of esophageal carcinoma were randomly divided into two groups: study group which received transfusion of radiated auto blood and radiotherapy, and control group which received radiotherapy only. The incidence of acute radiative esophagitis and changes of T cell subgroup and IL 2 were observed. RESULTS The incidence of acute radiative esophagitis was 12 1% in study group and 60 6% in control group ( P <0 01). The average dose of radiotherapy causing acute radiative esophagitis was 4050±823 (cGY) in study group, and 2460±609 (cGY) in control group ( P <0 01). Significant changes of IL 2 and T cell subgroups were seen in study group. CONCLUSION Low dose radiation can stimulate the immun function, through which the threshold dose of radiotherapy increases without damaging the normal tissues.