胃癌患者血清 MG抗原的研究

Preliminary studies on serum MGAg in patients with gastric cancer

目的ＭＧ抗原（ＭＧＡｇ）是一组新的胃癌相关抗原，本研究评价其临床应用价值及意义．方法应用胃癌单克隆抗体建立的一步法免疫放射分析法（ＩＲＭＡ）检测了４０例胃癌患者，３３例慢性良性胃病患者和２０例正常人血清中的ＭＧＡｇ．结果胃癌患者血清ＭＧＡｇ含量及阳性率明显高于正常人及良性胃病患者（Ｐ＜００１）；Ⅲ～Ⅳ期患者ＭＧＡｇ显著高于Ⅰ～Ⅱ期患者（Ｐ＜００５）；有远处和（或）区域淋巴结转移患者ＭＧＡｇ明显高于未有转移患者；贲门癌患者ＭＧＡｇ较胃窦、体癌高，但无统计学意义（Ｐ＞００５）．对１０例行胃癌切除术的ＭＧＡｇ阳性患者，术后１０ｄ～１４ｄ检测血清ＭＧＡｇ明显下降（Ｐ＜００１）．结论检测血清ＭＧＡｇ对胃癌诊断、判断胃癌病情、观察手术疗效及预后判断具有较高的临床价值．

AIM To evaluate serum Mg antigen (MGAg) in patients with gastric cancer and to investigate the relationship between MGAg and other biological factors. METHODS Serum MGAg contents of 40 cases of gastric cancer, 23 benign diseases, 20 healthy subjects were detected by immunoradiometeric assay. RESULTS Serum MGAg contents and positive rates in patients with gastric cancer were much higher than those of healthy subjects and those with benign diseases ( P <0 01) . Serum MGAg of stages Ⅲ and Ⅳ patients was significantly higher than that of stages Ⅰ and Ⅱ patients ( P <0 05) . Serum MGAg in patients with metastasis were much higher than that of patients without metastasis ( P <0 01) . Serum MGAg was decreased to normal level 10-14 days after surgical treatment in gastric cancer. CONCLUSION Determination of serum MGAg can play an important role in the diagnosis and the assessment of the prognosis in gastric cancer.