儿童特发性血小板减少性紫癜与幽门螺杆菌感染的关系

Relationship of idiopathic thrombocytopenic purpura and Helicobactor pylori in children

目的了解儿童特发性血小板减少性紫癜(ITP)与幽门螺杆菌(HP)的感染情况。方法采用13C尿素呼吸试验对正常儿童和ITP患儿进行HP检测。结果384例正常儿童中48例HP阳性,感染率12.5%,而267例ITP患儿中有60例HP阳性,感染率22.5%,ITP患儿的HP感染率显著高于正常儿童(P<0.01)。不同类型ITP患儿中,急性ITP的HP感染率为23.1%、慢性ITP为21.2%以及难治性ITP为21.4%,比较显示不同类型的ITP患儿HP感染率差异没有统计学意义(P>0.05)。结论本临床研究中,ITP患儿的HP感染率明显高于正常儿童,HP感染与儿童ITP的发病存在着密切联系。进一步分析显示不同类型的ITP患儿HP感染率差异没有统计学意义。

Objective To investigate the infection of helicobactor pylori（HP） in children with idiopathic thrombocytopenic purpura（ITP）. Methods Normal children and children witb ITP were detected by 13C urea breath test. Results 48 of 384 normal children were positive for HP infection （ 12.5% ）. 60 of 267 children with ITP were positive for HP infection （22. 5% ）. The infection rate of HP in children with ITP was higher than that in normal children（ P〈0.01 ）. The infection rate of HP in chilldren with acute, chronic and refractory ITP was 23.1% , 21.2% and 21. 4% respectively. The analysis showed there was no statistical significance in children with different type ITP （ P〉0. 05 ）. Conclusion The study had shown the infection rate of HP in children with ITP was higher than that in normal children, there seemed to associate with HP infection and ITP in children. The further analysis showed there was no statistical significance in children with different type ITP.