胎儿全前脑畸形的超声诊断价值浅析

Fetal holoprosencephaly syndrome analysis of ultrasonograghy

目的探讨二维及彩色多普勒超声(color doppler flow imaging,CDFI)诊断胎儿全前脑及其分型的临床价值。方法应用SEQUOIA512型彩色多普勒超声仪诊断16例全前脑畸形,观察胎儿颅内结构、颜面部状况、Willis动脉环结构及其血流灌注状况,以及合并其他部位畸形情况。结果16例超声诊断全前脑畸形胎儿中,10例诊断为无叶全前脑且部分合并颜面畸形、复杂先天性心脏病、手指畸形;5例诊断为半叶状全前脑;1例诊断为叶状全前脑。CDFI显示Willis动脉环不完整,表现为单支大脑动脉且伴有中断现象,出现反向血流或灌注正常。结论二维及CDFI超声是一种无创、敏感检测胎儿全前脑畸形及其分型的方法。

Objective To explore the clinical value of the 2 dimensional ultrasound（2DU） and color doppler flow imaging（CDFI） on the diagnosis and the type of holoprosencephaly syndrome（HPE） in fetuses. Methods Sixteen fetuses were diagnosed as HPE using ultrasonography, the encephalic struture, facial struture, the configuration and blood flow of Willis atery loop were observed with 2DU and CDFI. Results Ten cases were diagnosed as lobarholoprosencephaly, 5 semilobarho-lop rosencephaly and 1 plbarholoprosencephaly combined with congenital heart disease, facial abnormalities and et al. Willis artery loop was assessed with CDH and showed to be a single cerebral artery , an incomplete Willis artery loop with a block or reversal blood flow or partial to be normal. Conclusion It is a noninvasive, sensitivemethod of 2D ultrasound and CDFI to precisely detect HPE and its type.