59例高血压病人LPO与SOD和血液流变学关系探讨

Study on the relationship between LPO,SOD and hemorrheology in 59 aged hypertension patients.

目的探讨老年高血压病人过氧化脂质（ＬＰＯ）与超氧化物歧化酶（ＳＯＤ）和血液流变学的关系。方法５９例老年高血压病人和５６例健康老人分别测定血浆ＬＰＯ、ＳＯＤ，高切率全血比粘度、低切率全血比粘度、血浆比粘度、血球压积（ＨＴ）、血沉（ＥＳＲ）。结果老年高血压病人ＬＰＯ、高切率全血比粘度、低切率全血比粘度、血浆比粘度、ＥＳＲ显著增高，ＳＯＤ显著降低。ＬＰＯ与ＳＯＤ呈显著负相关，与高切率全血比粘度、低切率全血比粘度、血浆比粘度呈显著正相关。结论ＬＰＯ。

Objective To investigate the relationship between LPO,SOD and hemorrheology in the aged hypertension patients. Methods the levels of lipoperoxide (LPO) and superoxide dismutase(SOD)in plasma,whole blood relative viscosity,plasma relative viscosity,HT and ESR were measured in 59 aged hypertension patients and in 56 healthy elderly controls Results In these patients,LPO,whole blood relative viscosity,plasma relative viscosity and ESR were significantly increased,whereas SOD was significantly decreased.LPO was negatively correlated with SOD and positively correlated with whole blood relative viscosity and plasma relative viscosity. Conclusions the changes in LPO,SOD and hemorrheology were intimately related with the pathogenesis of aged hypertension.