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Saitohin基因Q7R多态性与肌萎缩侧索硬化的相关性研究 被引量：1

Association between Q7R polymorphism of saitohin gene and amyotrophic lateral sclerosis
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摘要 目的探讨中国人种Saitohin基因(STH)Q7R多态性与肌萎缩侧索硬化(amyotrophic lateral sclerosis,ALS)的发病相关性。方法采用病例对照研究,应用递减聚合酶链式反应限制性酶切片段长度多态性(Touchdown-PCR-RFLP)方法检测135例ALS患者和135例正常人STH基因Q7R多态性。结果所有DNA样本的STH基因均为QQ型纯合子。结论STH基因Q7R多态性与ALS无相关性。 Objective To evaluate the association between the Q7R polymorphism of saitohin gene（STH） and amyotrophic lateral sclerosis. Methods The Q7R polymorphism was examined in 270 subjects （ALS： 135; controls： 135） from China,by the Touchdown polymerase chain reaction restriction fragment length polyrnorphism（Touchdown PCR -RFLP）. Results Only QQ homozygote was found in the all subjects. Conclusion The results indicated that the Q7R polymorphism of STH gene was not associated with ALS.
作者 白杰 陈霞 谷伟 李爽 刘亚玲
机构地区 河北医科大学第二医院神经内科
出处 《临床荟萃》 CAS 2010年第4期292-294,共3页 Clinical Focus
关键词 肌萎缩侧索硬化 基因 聚合酶链反应 amyotrophic lateral sclerosis gene polymerase chain reaction
分类号 R745.49 [医药卫生—神经病学与精神病学]
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参考文献12

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共引文献4

同被引文献11

  • 1胡俊,史树贵,李露斯.神经系统疾病与超氧化物歧化酶[J].中国临床康复,2005,9(33):130-132. 被引量：8
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  • 9李一梅,刘宽芝.氧化应激、线粒体功能障碍与2型糖尿病[J].临床荟萃,2014,29(2):213-216. 被引量：26
  • 10韩秀华,孙丽华,邹健,孟亚红,范小红,王雪莲.还原型谷胱甘肽对多发性骨髓瘤患者沙利度胺相关的周围神经病变的保护作用[J].临床荟萃,2014,29(4):410-413. 被引量：5

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临床荟萃
2010年 第4期

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