纳络酮治疗肝性脑病的临床疗效研究

Study on Therapeutic Effects of Naloxone in Treatment of Patients with Hepatic Encephalopathy

目的探讨纳络酮治疗肝性脑病(HE)的临床疗效。方法将70例HE患者随机分为两组,治疗组在综合基础治疗上加用纳络酮,对照组仅用综合基础治疗。结果治疗组清醒时间明显短于对照组,两者比较差异具有统计学意义(P<0.05);治疗组病死率8.57%,对照组病死率14.28%,两者比较差异无统计学意义(P>0.05);治疗组总有效率为88.57%,对照组为57.14%,两者比较差异具有统计学意义(P<0.05)。结论纳络酮治疗可以明显缩短清醒时间,提高肝性脑病的治疗效果,并能减少病死率。

Objective To study the therapeutic effects of Naloxone on patients with hepatic encephalopathy （HE）. Methods 70 patients with HE were randomly divided into the treatment group and the control group. The former received naloxone on the base of a complex treatment and the latter only received a complex treatment. Results The time of awakening was shorter in the treatment group than that in the control group （P〈0.05）. The death rate was 8.57% in the treatment group and 14.28% in the control group, and there were no significant differences in two groups （P 〉 0.05）. The total effective rate was 88.57% in treatment group and was 57.14% in control group, and there were significant differences in two groups （P 〈 0.05）. Conclusion Naloxone in the treatment on patients with HE can shorten awakening time, improve therapeutic efficacy, and decrease the death rate obviously.