血尿酸及尿微量白蛋白水平与冠心病患者冠状动脉病变的关系探讨

Relationship between the levels of serum uric acid and uric micro-albumin and the coronary stenostic lesions in patients with coronary atherosclerotic disease

目的探讨冠心病患者血尿酸水平和尿微量白蛋白水平同冠状动脉病变程度及形态之间的关系。方法选取经冠状动脉造影证实的冠心病患者159例,检测血尿酸水平(UA)和晨尿白蛋白/肌酐浓度值(UACR),并结合冠状动脉造影所见的冠状动脉狭窄程度积分和有无复杂狭窄进行分析。结果有复杂狭窄组血UA水平及UACR较无复杂狭窄组者明显增高(P均<0.05);多因素逐步回归分析发现冠状动脉病变的严重程度与血清UA和UACR水平之间存在线性关系。结论血尿酸及尿微量白蛋白升高与冠心病患者的冠状动脉病变程度和形态有一定程度的关系。

Objective To investigate the relationship between the levels of serum uric acid and uric microalbumin and the morphology and degree of coronary stenostic lesions in patients with coronary atherosclerotic disease. Methods One hundred and fifty- nine patients were divided into two groups according whether complex stenosis was present or not. The degree of stenosis was analysed in terms of coronary stenosis index as well. The levels of serum uric acid （UA）were detected, and levels of micro-albuminuria was expressed by urinary ratio （UACR）. Results There were significant differences between the patients with complex stenosis and those without in terms of UA and UACR （P 〈 0. 05 ）. By the method of stepwise multiple linear regression and correlation, it is found that UA and UACR were linear related to the coronary stenosis index. Conclusion The increased levels of UA and UACR can contribute to the complex stenosis and the degree of coronary stenostic lesion in patients with coronary artery disease.