冠心病介入治疗前后心功能与胱抑素C的对比观察

Comparison of cardiac function and concentration of cystatin C before and after interventional therapy in the patients with coronary heart disease

目的探讨冠心病患者介入治疗前后心功能与血清胱抑素C(CysC)的变化。方法入选我院住院200例冠心病患者,应用超声心动图测量其介入前及介入后6个月的左心室室壁运动积分指数(WMSI)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)及左心室射血分数(LVEF);检验介入前及介入后6个月CysC浓度变化情况。结果介入治疗后WMSI及LVEF较术前明显改善,LVEDD及LVESD均较术前缩小,CysC较术前降低(P<0.01)。结论介入治疗可以改善冠心病患者心功能,降低CysC浓度。CysC可以作为心衰患者独立危险因子。

Objective To discuss the change of cardiac function and concentration of CysC from before and after imerventional therapy in patients with coronary artery disease. Methods In 200 hospital patients with coronary artery disease in our hospital, the WMSI, LVEF, LVEDD and LVESD before and after interventional therapy were measured by eehocardiography and the concentration of CysC in blood before and after interventional therapy were determined. Their results were compared. Results WMSI and LVEF after interventional therapy were significantly better than before interventional therapy. LVEDD and LEVSD after interventional therapy were smaller than before interventional therapy. The concentration of CysC after interventional therapy was lower than before interventional therapy （P 〈 0. 05 ）. Conclusion Interventional therapy can improve cardiac function of patients with coronary artery disease, and cut down the concentration of CysC. The concentration of CysC was a univariate predictor of patients with heart failure.