妊高征孕产妇静脉血血小板减低回顾性分析

Retrospective analysis of thrombocytopenia in venous blood in pregnancy-induced hypertension women

目的探讨药物源性妊高征孕产妇静脉血血小板减低的原因。方法分别对正常孕妇(83例)、妊高征孕产妇(181例)、对照组(正常非孕妇女29例)的血液标本进行血小板计数(PLT)、平均血小板体积(MPV)、血小板分布宽度(PDW)测定,对PLT<80×109显著性血小板减低进行纠正复查。结果181例妊高征住院孕产妇血小板显著减低27例,占14.92%;83例正常孕产妇血小板显著减低2例,占2.41%(χ2=9.1041,P=0.0026)。妊高征组和正常孕妇组的MPV、PDW显著高于对照组(P<0.05);妊高征组MPV、PDW明显高于正常孕妇组(P<0.05);妊高征组的PLT显著低于对照组(P<0.05)。经手工或预稀释法检测,27例妊高征中19例得以纠正,占70.4%(χ2=11.4183,P=0.0007)。结论妊高征孕产妇血小板减少者,可经急诊预先稀释法或手工计数纠正确诊,对检测妊高征的发展有一定参考意义。

Objective To investigate the reason of drug-induced thrombocytopenia in pregnancy-induced hypertension（PIH）. Methods Eighty-three normal pregnant women, 181 PIH women, 29 normal unpregnancy women （control group） were studied, platelet count （PLT）, mean platelet volume （MPV）, platelet distribution width （PDW） were measured. When determination value was 〈 80 - 109 platelets the correct review were performed. Results In 181 cases of PIH women there were 27 womens with significant platelet reduction, the reduced rate was 14.92% ;In 83 normal pregnant women there were 2 women with significant platelet reduction, the reduced rate was 2.41% ;The difference between two groups had statistical significance （X^2 =9. 1041 ,P =0. 0026）. MPV and PDW in PIH group and normal pregnant women group significantly higher than those in control group （ P 〈 0. 05 ） ; MPV and PDW in PIH group were significantly higher than those in normal pregnant women group （ P 〈 0. 05 ） ; PLT in PIH group wss significantly lower than that in the control group （ P 〈0. 05 ）. By hand or pre-flilution method, In 2＂/with significant platelet reduction 19 cases be corrected, accounting for 70. 4% ,the difference between two groups before and after correction had statistical significance （X2 = 11. 4183 ,P = 0. 0007 ）. Conclusion The diagnosis of thrombecytopenia in PIH women can be corrected by emergency pre-dilution method or manual count, the detection has a certain reference value on the development of PIH.