艾迪注射液联合CTF方案新辅助化疗对乳腺癌的疗效评价及血清sFas的影响

Evaluation of Efficacy on Breast Cancer Treated by Aidi Injection plus CTF Program of Neoadjuvant Chemotherapy and the Impacts on Serum sFas

目的观察艾迪注射液联合CTF方案新辅助化疗对乳腺癌的近期疗效、不良反应及血清sFas的影响。方法将48例乳腺癌患者随机分为艾迪注射液联合CTF方案治疗组(28例),CTF方案对照组(20例),分别对两组患者近期疗效评价、不良反应进行比较,采用酶联免疫吸附试验(ELISA)法检测化疗前后的血清sFas水平变化。结果治疗组有效率为92.86%,对照组为90.00%,两组比较无显著性差异(P>0.05);治疗组消化道反应、心功能变化、外周白细胞和血红蛋白下降程度低于对照组(P<0.05);治疗组患者生活质量、肝功能及心肌酶的改善明显优于对照组(P<0.05,P<0.01);治疗组及对照组血清sFas水平明显降低,两组比较有显著性差异(P<0.05)。结论艾迪注射液联合CTF方案能够显著提高化疗疗效,减轻不良反应、提高患者生活质量;并能够降低乳腺癌患者血清sFas浓度,有可能成为乳腺癌治疗的新靶点。

Objective To observe the short -term efficacy,adverse reaction and the impacts of serum sFas on breast cancer treated by Aidi injection plus CTF program of neoadjuvant chemotherapy. Methods 48 cases of breast cancer were randomly divided into two groups, treatment group of Aidi injection plus CTF program （28 cases）and control group of CTF program （20 cases）. The comparison of two groups was performed in the evaluation of short - term efficacy and adverse reaction respectively. ELISA was adopted to determine serum sFas level before and after chemotherapy. Results The effective rate was 92.86% in treatment group and was 90.00% in control group ,without significant difference in comparison between two group （P 〉 0.05 ）. In treatment grnup, digestive reaction, the changes in heart function and the decrease degree of peripheral white blood cell and hemoglobin were inferior to those in control grnup（ P 〈 0.05 ）. The improvements in life quality,liver function and myocardial enzyme were superior obviously to those in control group （P 〈 0. 05,P 〈 0.01 ）. Serum sFas level decreased obviously in either treatment group or control group and significant difference presented in comparison between two groups （ P 〈 0.05 ）. Conclusion Aidi injection plus CTF program improves chemotherapy efficacy,reduce the toxicity, promote life quality of patients significantly;and it decreases serum sFas concentration in the patients with breast cancer. Hence,this therapy becomes possibly a new target for the treatment of breast cancer.