食管癌患者手术前后血清IL-6和SIL-6R检测及其临床意义

The Measurement of Serum Interleukin 6 and Soluble Interleukin 6 Receptor in Patients with Esophageal Carcinoma before and after Operation and its Clinical Significance

目的：探讨血清白介素6（IL－6）、可溶性白介素6受体（SIL－6R）在食管癌发病中的作用。方法：应用夹心酶联免疫吸附法（FAISA）测定了30例手术前后食管癌及30例健康对照者血清IL－6、SIL－6R水平，同时测定了血清C反应蛋白（CRP）。白介素4（IL－4）水平。结果：食管癌患者术前血清IL－6和SIL－6R水平显著高于健康对照者（27．2±7．9ng／L、41．3±12.0μg/L比16．1±1．3ng/L、31．5±127nμg/L，P均＜0．01）；食管癌患者术后血清IL－6和SIL－6R水平又高于术前（535±士22．0ng/L、53．3±14．0μg/L比27．2±7．9ng／L、41．3±12．0μg/L，P均＜0.01）。结论：血清IL－6、SIL－6R可能参与食管的发病过程；食管癌患者术后血清IL－6、SIL－6R升高可能与手术后应激有关。

To evaluate the roles of serum interleukin 6 and soluble interleukin 6 receptor in the development of esophageaal carcinoma. Methods: Serum levels of interleukin 6 (IL- 6) and soluble interleukin 6 receptor(sIL- 6R) in 30 cases of preoperative and postoperative esophageal carcinoma and 30cases of healthy subjects were measured with a Sandwich ELISA method. Serum c-reactive protein(CRP)and interleukin 4(IL- 4 ) were determined simultaneously. Results: serum levels of IL- 6 and sIL- 6R inpreoperativ esophageal carcinoma were higher than those of healthy controls(27. 2 ± 7. 9ng/L.41 .3±12 .0 μg/L vs 16. 1 ± 1. 3 ng/L.31. 2 ± 12.7 μg/L, respectively, p < 0.01 ), Serum levels of IL - 6 andsIL- 6R in postoperative esophageal carcinoma were much higher than those in preoperative esophagealcarcinoma(53. 5 ± 22 .0 ng/L, 53 .3 ± 14.0 μg/L vs 27. 2 ± 7 .9 ng/L, 41 .3 t 12.0 μg/L, respetively,P < 0 .01 ). Conclusions: serum IL- 6. sIL- 6R may participate in the development of esophageal moma; That the elevation of serum levels of IL- 6 and sIL - 6R in postoperation were higher than those inpreoperation may be related to operative stress.