立体适形放射治疗非小细胞肺癌复发患者的疗效评价

Evaluation of the efficacy of three-dimensional conformal radiation therapy in patients with recurrent non-small cell lung cancer

目的:观察立体适型放射治疗对非小细胞肺癌放射治疗后复发患者的疗效和放射反应。方法:对54例常规放射治疗后局部复发的非小细胞肺癌患者给于立体定向放射治疗,剂量为4.5～6.0Gy/次,隔日1次,肿瘤病灶总剂量为50～65Gy。结果:CR为18.5%(10/54)、PR为70.4%(38/54)、SD为7.4%(4/54)、PD为3.7%(2/54),总有效率为88.9%;1、2年生存率分别为63.0%(34/54)和25.9%(14/54);放射反应以放射性食管炎、放射性肺炎及肺纤维化为主,大多为Ⅰ～Ⅱ级,患者均可耐受。结论:立体适型定向放射治疗对局部晚期放疗后复发的非小细胞肺癌患者有较好的疗效和耐受性。

Objective： To observe the three-dimensional fitness-type radiation therapy on non-small cell lung cancer recurrence after radiotherapy in patients with the efficacy and radiation reactions. Methods： 54 patients with local recurrence after conventional radiotherapy in non-small cell lung cancer patients to stereotactic radiotherapy at the dose of 4.5 to 6.0 Gy per times,every other day,tumor lesions total dose of 50 to 65 Gy.Results： CR of 18.5%（10/54）,PR of 70.4%（38/54）, SD of 7.4%（4/54）, PD of 3.7%（2/54）,the total effective rate was 88.9%.1-year,2-year survival rates were 63.0%（34/54） and 25.9% （14/54）,radiation reaction to radiation esophagitis, radiation pneumonitis and pulmonary fibrosis, mainly mostly Ⅰ～Ⅱ grade, can be tolerated. Conclusion： The three-dimensional fitness-based radiotherapy for recurrence after radiotherapy for locally advanced non-small cell lung cancer have better efficacy and tolerability.