早期营养程序化与远期肥胖

Early nutritional programming and later obesity

流行病学研究表明，肥胖与众多代谢疾病如2型糖尿病、高血脂、高血压等之间存在密切关系，生命早期的营养可以对机体造成程序化的影响，机体对母亲妊娠期及哺乳期不良营养刺激可以通过整体、细胞、分子水平做出适应性反应。这些反应将持续改变机体的生理和代谢，进而增加肥胖和代谢相关疾病的风险。

Epidemiological studies indicate that obesity is associated with metabolic disorders, such as type 2 diabetes, hyperlipidemia and hypertension. Early nutrition, especially during pregnancy and lactation can lead to the permanent programming of system by some adaptive effects in physiological,cellular and molecular levels. These adaptive effects persistently changed the metabelie throughout life, hence resulted in increased risk of obesity and metabolic related disease. This review focuses upon the influence of nutrition in early life on adulthood obesity and researches on their pathophysiologieal mechanism.