奥曲肽治疗肠梗阻临床观察

The clinical analysis of bowel obstruction treated by octreotide

目的:探讨奥曲肽在肠梗阻治疗中的作用。方法:2007年2月～2009年1月本科93例肠梗阻患者分治疗组(45例)和对照组(48例),两组年龄、性别及肠梗阻病因比较,差异无统计学意义。对照组给予常规治疗,包括禁饮食,胃肠减压,石蜡油胃管内注入,纠正水电解质及酸碱平衡紊乱,胃肠外营养(TPN),抗生素。治疗组除上述常规治疗外,加用奥曲肽0.2mg+0.9%氯化钠液50ml,8h1次,持续缓慢静脉注射(25μg/h),至梗阻解除。观察两组临床症状改善情况、肛门排气时间、平均住院天数等。结果:奥曲肽组用药后临床症状在2d内消失占86.61%,肛门排气时间明显提前,平均住院天数缩短3.13d,差异有统计学意义。结论:奥曲肽在治疗肠梗阻上是一种有效、安全的药物。

Objective：To investigate the effect of octreotide in patients with bowel obstruction. Methods：93 cases of bowel obstruction selected in our department from February 2007 to January 2009 were divided into two groups： treatment group （45 cases） and control group （48 cases）. There was no significant difference on the two groups between age, gender and cause of disease. The patients in the control group were treated with routine therapy including fasting, gastrointestinal decompression, injection of paraffin liquid from gastric tube, intravenous replacement of fluid and electrolytes ,total parenteral nutri tion and antibiotics. The patients in the treatment group received continuous intravenouslyinjection octreotide （25 μg/h） plus routine therapy, until obstruction was released.Investigated the remission of symptoms, the anal exhaust time and the average hospitalization time in the two groups. Results：After treatment, the remission rate of symptoms in the first two days of treatment group was 86.61%, the average annual exhaust time was significantly earlier than that in control group （ P0.05）. And the average hospitalization time of treatment group was 3.13 days shorter than that of control group （P0.05）. Conclusion： Octreotide is efficient safe in the treatment of bowel obstruction.