清胰汤对急性胰腺炎患者血管活性物质含量的影响

The effect of Qingyi decoction on Vaso-active substance in acute pancreatitis patieuts

目的:从胰腺血液循环障碍的角度探讨清胰汤治疗急性胰腺炎(AP)的机制。方法:将56例AP患者分为观察组(30例)及对照组(26例),前者给予西药联合清胰汤治疗,后者单纯给予西药治疗,比较血管活性物质一氧化氮(NO)及血栓素B2(TXB2)的含量,同时比较白细胞计数(WBC)、血清胰淀粉酶(AL)、C反应蛋白(CRP)的含量。结果:治疗前两组患者的NO显著降低,治疗后呈不同程度回升,且观察组高于对照组(P<0.05);治疗前两组TXB2、WBC、AL及CRP显著升高,治疗后有所下降,且观察组低于对照组(P<0.05)。结论:清胰汤可能是通过增加NO含量、降低TXB2含量,以缓解血管阻力,改善胰腺血液循环,减轻胰腺组织坏死,从而发挥治疗AP的作用。

Objective： To observe the mechanism of Qingyi decoction to treat acute pancreatitis （AP）. Methods： 56 AP pa tients were divided into two groups： observation group（30 cases） and control group（26 cases）. Basing on the treatment of western medicine, the observation group was given Qingyi decoction, twice a day, but the control ones were not. The vasoactive substance including nitric oxide （NO） and thromboxane B2（TXB2） were detected, so were the leucocytes（WBC）, serum amylase（AL）and C reaction protein （CRP）. Results： The quantity of NO was low before treatment, but it increased after being treated, especially NO in the observation group was significantly higher than that of control group（P0.05）. The TXB2, WBC, AL and CRP were high before treatment, but it decreased after being treated, and the upper 4 indexes in observation group was significantly lower than that of control group （P0.05）. Conclusion： Qingyi decoction could increase quantities of NO and decrease TXB2, suggesting it could relieve the obstruction of in the vessels and improve blood circulation and alleviated putrescence of the pancreas, which might be a potential mechanism of Qingyi decoction to treat acute pancreatitis.