补肾健脾中药对妊娠大鼠孕激素及其受体的影响

Effect of Kidney-tonifying and Spleen-invigorating Herbal Medicine on Serum Progesterone and Progesterone Receptor in Pregnant SD Rats

为探讨补肾健脾中药对妊娠大鼠子宫蜕膜孕激素受体的影响，设计了补肾健脾药“助孕３号丸”（菟丝子、川续断、桑寄生、党参、黄芪等组成），并通过建立米非司酮（ＲＵ４８６）流产模型，设立阳性药和空白对照与之对照观察。结果表明“助孕３号丸”能促使孕激素分泌，并使ＲＵ４８６与孕激素受体的结合率降低，提示该药可能在受体水平促进黄体功能，从而起到保胎作用。

Zhuyun Ⅲ Pill(ZYⅢ) was specially prepared to explore the effect of kidney-tonifying and spleen-invigorating herbal medicine on progesterone receptor of uterine decidua in pregnant SD rats. The abortive rat model was set up with mifepristone (RU486) and the control group was also established. The results showed that ZYⅢ promoted the secretion of progesterone and inhibited the binding of RU486 to progesterone receptor. It is suggested that ZYⅢ could improve the function of corpus luteum and this will supply a theoretical evidence for the kidney_tonifying and spleen_invigorating herbal medicine in preventing and treating the spontaneous abortion.