撤去抗精神病药后精神症状复发的相关因素分析

Related factors analysis for relapse of psychosis symptom of withdrawal antipsychotic drugs.

目的研究停用抗精神病药物所致反应的相关因素。方法对７１例口服抗精神病药的精神分裂症患者，采用递减法３～５天内将药物全部撤去，并在停药前、停药二周末分别进行ＢＰＲＳ、ＳＡＰＳ、ＳＡＮＳ、ＴＥＳＳ和催乳素浓度测定。结果停药后２７例复发占３８％；停药后较停药前ＢＰＲＳ、ＳＡＰＳ和ＴＥＳＳ显著增高（Ｐ＜００５），ＳＡＮＳ则无明显变化；复发者较未复发者的催乳素浓度降低（Ｐ＜００５）。结论不同年龄、剂量、病程与疾病复发无关。

Objective The purpose of this paper was to examine the related factors for relapse of psychosis symptom of withdrawal antipsychotic drugs.Methods 71 inpatients with schizophrenia who were taking antipsychotic drugs orally,were discontinued all medications gradually within 3 to 5 days.The rating scales of BPRS,ASPS,SANS and TESS were used for the evaluation of clinical symptoms and side effects and plasma prolactin concentration was measured by radioimmunoassay.Before and after two-weeks drop-out.Results 27 patients(37%) relapsed.The total scores of BPRS,SAPS and TESS were signficantly elevated after discontinued treartment.No difference was noted in the total score of SANS before and after drop-out.Plasma prolactin level was significantly lower in patients who recurred than those who didn't relapse.Conclusion There are no correlations between recurrence and the age,dosage,and course of illness.The change of plasma prolactin level may be related to the recurrence.