中期妊娠引产的临床研究

The Clinical Study of Induction of Labor in Midpregnancy Patients

目的探讨米非司酮配伍利凡诺尔用于14～27周中期妊娠引产的可行性、临床效果、安全性、缩短引产时间和减轻患者痛苦等方面的研究。方法回顾性分析佛山市三水区人民医院在2007年12月至2008年12月期间接受的自愿要求引产的中期妊娠108例临床资料,随机将患者分成试验组与对照组,试验组采用米非司酮配伍利凡诺尔进行引产,共计55例,对照组采用利凡诺尔进行引产,共计53例,比较二者在药物起效时间、发动宫缩直至胎儿胎盘娩出时间及整体时间的差异。结果在药物起效时间方面,试验组平均28小时34分,对照组平均38小时25分;在发动宫缩直至胎儿胎盘娩出时间,试验组平均7小时58分,对照组平均13小时12分;在整体时间方面,试验组平均35小时52分,对照组平均48小时46分;所有时间试验组明显短于对照组,两组间有显著性差异,有统计学意义(P<0.05)。结论米非司酮联合利凡诺尔用于14～27周中期妊娠引产,可明显缩短引产时间,提高成功率、较少清宫率、减少宫腔操作、减轻因此带来的疼痛,减少患者在医院的住院天数,是一种安全、有效的中期妊娠引产方法,值得临床应用并推广。

Objective To investigate the feasibility, clinical effects, safety, shorten the induction time and alleviate pain about 14 to 27 weeks induction of labor in midpregnancy patients treated by mifepristone combined with rivanol. Method From December 2007 to December 2008, retrospective analysis of people＇ s hospital of Sanshui district induction of labor in midpregnaney patients 108 eases, they were randomly divided into test group and control group, experimental group mifepristone combined with rivanal for induced abortions, for a total of 55 cases of control group used for induction of labor Rivanal, for a total of 53 cases, to compare the onset time in the drug launched until uterine fetal placental delivery time and overall time difference. Results The onset time in the drug, the test group an average of 28 hours 34 minutes, the control group average of 38 hours 25 minutes; launched contraction in the fetus until the placenta delivery time, the test group an average of 7 hours and 58 minutes, the control group average of 13 hours 12 minutes ; in the overall timing, the test group an average of 35 hours 52 minutes, the control group average of the average 48 hours 46 minutes; all the time trial was significantly shorter than the control group, between the two groups were significantly different, there are statistically significant （P〈0.05）. Conclusion 14 to 27 weeks induction of labor in midpregnancy patients with mifepristone combined with rivanal, can significantly reduce the induction time and increase the success rate, less removal of endometrial rate, to reduce the uterine cavity operation, to alleviate the pain, and reduce patients in the hospital in-patient days, its a safe and effective method of induction of mid-pregnancy, and to is worth and to promote the clinical application.