甲氨蝶呤与来氟米特联合使用治疗类风湿性关节炎86例临床分析

Clinical Analysis of 86 Cases with Rheumatoid Arthritis Treated by Methotrexate Combined with Lefunomide

目的评价甲氨蝶呤联合来氟米特联合使用治疗类风湿性关节炎的有效性。方法将86例类风湿性关节炎患者随机分成两组。治疗前后对患者进行晨僵时间、关节疼痛(压痛)数、关节肿胀数等症状和体征的评估,并做好记录,比较两组的总有效率。结果治疗组无效3例,显效9例,有效23例,明显有效11例,总有效率93.5%。对照组无效10例,显效7例,有效19例,明显有效4例,总有效率75.0%。二者在总有效率的比较上,P<0.05差异有统计学意义。结论甲氨蝶呤联合来氟米特联合用药在治疗类风湿性关节炎上有明显的优势,值得广泛推广。至于二者合用的不良反应,还有待于进一步的深入研究。

Objective To evaluate the the methotrexate and Lefunomide combined treatment of rheumatoid arthritis. Methods Patients with rheumatoid arthritis 86 cases were randomly divided into two groups. Before and after the treatment, estimate the patients of the morning stiffness of time, joint pain （tenderness）, joint swelling number of symptoms and signs of assessment, and make records, and the total effective rate of two groups. Results Treatment group, there are 3 cases of invalid, powerfully 9 cases, effectively 23 cases, obviously effective 11 cases, the total effective rate is 93.5%. Control group, there are 10 cases of invalid, powerfully 7 cases, effectively 19 cases, obviously effective 4 cases, the total effective rate is 75.0%. In the total effective rate of comparative of two groups, P〈0.05, there are statistically significant differences. Conclusion Methotrexate and Lefunomide combination in the treatment of rheumatoid arthritis has obvious advantages, being worth popularizing widely. For both share side effects, They remain to be further in-depth study.