摘要
目的探讨通心络治疗血管性痴呆(VD)的临床疗效。方法将入选的病例随机分为两组,治疗组62例,对照组63例。对照组给予控制血压、抗血小板、神经保护等常规治疗。治疗组患者在常规治疗基础上加服通心络胶囊,3次/d,每次1.52g(4粒),1个疗程为4周,共3个疗程。治疗前和每个疗程结束后以长谷川痴呆量表(HDS)和简易智力状态检查表(MMSE)得分作为疗效评定。治疗前后查血尿常规、血糖、肝肾功能、心电图、血压、症状变化、记录药物不良反应。结果治疗组患者治疗4周后(HDS、MMSE得分较对照组差异无显著性(P>0.05),治疗8周后治疗组较对照组差异有显著性(P<0.05),治疗12周后治疗组较对照组差异有非常显著性(P<0.01)。结论通心络治疗血管性痴呆的智能减退临床有明显疗效,不良反应少。
Objective To explore the effect of Tongxinluo capsule on vascular dementia. Methods The enrolled patients were randomly divided into control group （n=63） and tongxinluo capsule group （n=62） .All the patients were treated with antibypertension, antiplatelet aggregatory and neuroprotection. In addition, the patients of tongxinluo capsule group were given 4 capsules of 3 times every day for 3 period of treatment of 12 weeks. All the patients were evaluated by HDS, MMES, blood test, urine test, liver function, kidney function ,electrocardiogram, blood pressure, blood sugar, symptomatic variation side effect before and after every period of treatments. Result compared with control group, the score of MMES and HDS of the patients in tongxinluo group had difference （P〈0.05）and significant difference （P〈0.01） after 4 and 8 weeks. Conclusion Tongxinluo capsule is effective on amentia of VD patients with less side effect.
出处
《中国医药指南》
2010年第4期7-9,共3页
Guide of China Medicine
关键词
血管性痴呆
通心络胶囊
临床观察
Vascular dementia
Tongxinluo capsule
Clinical observation
