摘要
目的探讨卵巢切除所致肾虚对Ⅱ型胶原诱导的小鼠关节炎(CIA)的影响及细胞因子的作用。方法于DBA/1小鼠皮下注射Ⅱ型胶原制作关节炎模型;以依赖株细胞增殖反应法测定IL-2、IL-6含量。结果卵巢切除可使关节炎小鼠脾单个核细胞的IL-2和IL-6含量显著增加;同时小鼠关节肿胀程度、滑膜组织增生、软骨损伤及软骨下骨的破坏均明显加重。结论IL-2、IL-6与CIA发病过程密切相关,卵巢切除所致肾虚可使CIA病变进一步加重,在一定程度上反映了此法所致肾虚与IL-2。
AIMS:to explore the effect of kidney-asthenia on CIA and the role of interleukins.METHODS:Arthritic model was made by subcutaneous injection of type two collagen;The content of IL-2 and IL-6 were determinated with cellular proliferative reaction.RESULTS: Ovariectomy made the content of IL-2 and IL-6 enhance,and the articular swelling,synovial proliferation,cartilage degeneration and bone destruction exacerbate apparently.CONCLUSION:IL-2 and IL-6 is closed relative to CIA,Ovariectomy can make the pathological changes of CIA exacerbate.The result shows that there are internal relations among kidney-asthenia,IL-2 and IL-6.
出处
《中国中医基础医学杂志》
CAS
CSCD
1998年第10期33-35,共3页
JOURNAL OF BASIC CHINESE MEDICINE
关键词
肾虚
卵巢切除
胶原诱导
关节炎
IL-2
IL-6
Kidney-asthenia\ Ovariectomy \ Interleukin-2\ Interleukin-6\ Collagen induced arthritis