小脑顶核电刺激对心律失常患者症状的影响

Influence of Fastigial Nucleus Stimulation on the Symptoms of Patients with Arrhythmia

目的探讨小脑顶核电刺激(fastigial nucleus stimulation,FNS)对非恶性心律失常患者症状的疗效。方法随机选择一段时期,对反复心悸为主诉就诊的病人,进行24h动态心电图检查有心律失常(室上性早搏、短阵室上性心动过速、室性早搏),且曾给予1种或几种抗心律失常药物治疗病情无好转者45例,用小脑顶核电刺激治疗,每次治疗40min,每周2次,每位患者治疗15次左右。观察症状改善情况。结果FNS治疗心悸、失眠、胸闷、头昏/头痛、乏力的有效率分别为80.0%、76.9%、81.5%、87.1%和82.9%;FNS治疗后心悸、失眠、胸闷、头昏/头痛、乏力评分降低,差异有统计学意义(P<0.01)。结论FNS治疗能有效改善非恶性心律失常患者的心悸、失眠、头昏/头痛、胸闷、乏力等症状。

Objective To explore curative effect of fastigial nucleus stimulation（FNS） in treating the symptoms of patients with nonmalignant arrhythmia. Method In a random period, FNS was used to treat 45 patients who went to hospital for repeating palpitation, and had arrhythmia （supraventricular premature beats, supraventricular runs, ventricular premature beats） confirmed by 24 h holter monitoring electrocardiogram, and whose state of illness did not improve after being treated by one or several antiarrhythmic drugs. After those patients were treated by FNS 40 minutes a time, twice a week, or so 15 times, the changes of symptom were observed. Results Effective rates of FNS in treating palpitation, sleep disorder, chest distress, dizziness/ headache and hypodynamia were 80.0 %, 76.9 %, 81.5 %, 87. 1 % and 82.9 % respectively. After treatment by FNS,the scores of palpitation, sleep disorder, chest distress, dizziness/headache and hypodynamia significantly decreased（P〈0.01）. Conclusion FNS can effectively improve symptoms of palpitation, sleep disorder, chest distress, dizziness/headache and hypodynamia of patients with nonmalignant arrhythmia.