氟哌啶醇对精神分裂症超氧化物歧化酶的作用

Effect of haloperidol on superoxide dismutase in schizophrenic patients

目的：探讨精神分裂症自由基代谢酶超氧化物歧化酶（ＳＯＤ）在氟哌啶醇治疗前后的变化。方法：用固定剂量氟哌啶醇治疗４６例慢性精神分裂症患者１２周，在治疗前后应用放射免疫法测查血ＳＯＤ含量，并评定ＢＰＲＳ、ＳＡＰＳ和ＳＡＮＳ量表。结果：治疗前ＳＯＤ值与ＳＡＰＳ总分正相关（Ｐ＜０．０５）。治疗后，治疗前高ＳＯＤ组明显降低，而低ＳＯＤ组明显增高（Ｐ均＜０．０５）。阴性型亚组中，治疗前ＳＯＤ值与治疗前后ＳＡＮＳ总分差值正相关（Ｐ＜０．０５）。结论：抗精神病药对ＳＯＤ值有双向调节作用；治疗前患者ＳＯＤ水平可能预测阴性症状的疗效。

Objective:To study of effect of haloperidol treatment on superoxide dismutase (SOD) in chronic schizophrenic patients. Method:Plasma SOD level was measured with immunoradiometric assay in 46 inpatients with diagnosis of chronic schizophrenia according to CCMD 2 R,before and after treatment with haloperidol (0 25mg/kg/d).The finding was compared with 25 healthy controls.The SOD level before treatment was classified into high and low according to the control norm.The clinical subjects were also assessed with the BPRS,SAPS and SANA before and after treatment. Results:Positive correlation was found between SAPS and SOD level before ( P <0 05) but not after treatment.The SOD level decreased in the ‘high’and increased in the ‘low’subgroup after treatment ( P <0 05).In patients with positive or mixed symptoms,there was positive correlation between the reduced SAPS subscore 2 and the change of SOD level with treatment.In patients with mainly negative symptoms,there was positive correlation between the pretreatment SOD level and the change of SANS score with treatment. Conclusion:Antipsychotic medication could produce change of SOD level in both directions depending on the pretreatment status.The SOD level,reflecting activity of positive symptoms could help to monitor the course of illness in addition to clinical assessment.For patients with negative symptoms,the pretreatment level of SOD could be a reliable outcome indicator with neuroleptic treatment.