精神分裂症语音和音乐刺激时的闭眼眼球活动

Closed eye movements in schizophrenic patients under verbal and musical stimulation.

目的：探索精神分裂症患者在语音和音乐刺激时闭眼眼球活动的特征。方法：对７０例精神分裂症，３４例情感性精神障碍和３３例正常对照者进行语音和音乐刺激，观察其闭眼眼球活动（ＣＥＭＳ）的变化。结果：精神分裂症组中，ｒ波次数的平均秩和与情感性精神障碍相似，但高于正常对照组（Ｐ＜０．０１）；ｓ波则分别低于后二者（Ｐ＜０．０５～０．０１）；此外，每次语音刺激前和刺激时的ｒ波次数均无显著性差异。ＣＥＭＳ值与ＢＰＲＳ、ＳＡＮＳ、ＳＡＰＳ总分以及药物剂量之间多数无显著性相关。结论：可见精神分裂症患者的ＣＥＭＳ存在着明显障碍。

Objective:To study the effect of verbal and musical stimulation on closed eye movements (CEMS) in schizophrenic patients. Method:CEMS was recorded with electro occulograph in 70 cases of schizophrenia, 34 manic depressives and 33 normal controls.The mental state was monitored with BPRS,SANS and SAPS. Results:The mean rank sum of the number of r wave in the schizophrenic group was similar to that of the manic depressive but significantly higher than the controls ( P<0 01 ) while that of S wave were markedly lower than both of the latter groups ( P<0 05 & P<0 01 respectively).There was also no significant change in the number of r wave before and after verbal stimulation.No significant relationship was found between the CEMS and most clinical parameters like the BPRS,SANS,SAPS and dosage of neuroleptics. Conclusion:Abnormalities of CEMS in schizophrenic patients may represent specific biological marker for the disease.