血脂水平与颈动脉粥样硬化状况的关系研究——附147例颈动脉超声分析

The Association between Blood Lipids and Carotid Atherosclerosis——147 Cases with Carotid Sonography

目的：研究血脂（血清总胆固醇及甘油三酯）水平与颈动脉粥样硬化的关系，评价高脂血症在颈动脉粥样硬化形成中的作用。方法：将１４７例患者分为对照组和颈动脉粥样硬化组，进行颈动脉超声检测及血清总胆固醇（ＴＣ）和甘油三酯（ＴＧ）水平的测定，以双侧颈动脉内膜—中层厚度的最大值（ＩＭＴｍ）作为评价颈动脉粥样硬化严重程度的指标，并进行颈动脉粥样硬化的危险因素分析。结果：颈动脉粥样硬化组的ＴＣ、ＴＧ水平显著高于非颈动脉粥样硬化组（Ｐ＜０．０１，Ｐ＜０．０５），且随ＩＭＴｍ的增厚，ＴＣ和ＴＧ水平呈上升趋势。ＴＣ与ＩＭＴｍ呈较显著的正相关（ｒ＝０．３４９２，Ｐ＜０．００１），ＴＧ与ＩＭＴｍ呈较弱的正相关（ｒ＝０．２７６０，Ｐ＜０．０５）。颈动脉粥样硬化的多因素分析表明，高胆固醇血症是颈动脉粥样硬化的主要危险因素之一。结论：超声测定颈动脉ＩＭＴｍ和定期检查血脂水平尤其是血清总胆固醇（ＴＣ）水平。

urpose:To assess the relationship between blood lipids and carotid atherosclerosis,and evaluate the action of hyperlipidemia to atherosclerosis.Methods:147 Subjects consisted of carotid atherosclerosis(CAS) and noncarotid atherosclerosis(nonCAS) were examined with carotid sonography.The maximum intimalmedial thickness (IMTm)of bilateral carotid arteries were measured.The blood total cholesterol(TC),triglyceride(TG) and other risk factors of atherosclerosis were tested,either.Results:the level of TC and TG were higher in CAS than in nonCAS(P<0.01,P<0.05),and they increased with the thicken of IMTm.TC and TG showed positive correlation with IMTm(r=0.3492,P<0.001;r=0.2760,P<0.05).The multivariable analysis showed that hypercholesterolemia were one of the main risk factors of CAS.Conclusion:sonographically tested carotid IMTm and the level of blood lipids,especially TC should be indicators in the diagnosis of early atherosclerosis.