摘要
粘细菌能够产生多种次级代谢产物,这些产物具有多种生物活性和作用机理,部分次级代谢产物有很高的抗肿瘤活性,对多种肿瘤细胞有抑制作用。本文主要综述粘细菌抗肿瘤次级代谢产物(如,埃博霉素、芮唑坡丁、双萨拉唑、特吡莱辛等)的化学结构和活性研究进展。
Myxobacteria are extraordinary producers of secondary metabolites with various biological activities and mechanisms of action. Many of those compounds demonstrated high cytotoxicity against human tumor cells. In this paper,we summarized the structural and biological characteristics of myxobacterial secondary metabolitcs with the capacity of anticancer, such as, Epothilone, Rhizopodin, Disorazole, Tubulysin.
出处
《齐鲁药事》
2010年第1期38-43,共6页
qilu pharmaceutical affairs
基金
山东省博士后创新项目专项资金(No.200903077)资助
