一种新的四肽(TFA-Gly-Pro-Thr-Ala-OH)合成工艺

Synthesis of TFA-Gly-Pro-Thr-Ala-OH

目的确定一种新的四肽(TFA-Gly-Pro-Thr-Ala-OH)合成工艺。方法以Boc-Gly-OSu、Boc-Thr-OSu、丙氨酸和脯氨酸为原料,选择适当的反应条件,得Boc-Gly-Pro-Thr-Ala-OH,再通过反应生成更稳定的目标产物。结果收率较高,质量稳定。结论本合成的新的四肽在收率、有关物质等方面都符合要求。

OBJECTIVE To establish a new synthetic route of TFA--Gly--Pro--Thr--Ala--OH. METHODS Selected appropriate reaction conditions,with Boc--Gly--OSu,Boc--Thr--OSu,alanine and proline as the raw materials,Boc--Gly--Pro --Thr--Ala--OH was get,then the more stable target product was made through the reactions. RESULTS The method has a high yield and stable quality. CONCLUSION The yield and related substance of the new tetrapeptide obtained by this route were met with the requirements.