摘要
目的了解血清脯氨酸肽酶(PLD)与乙型病毒性肝炎纤维化程度的关系。方法测定217例乙型肝炎患者血清中PLD水平,利用ROC曲线分析丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、AST/ALT和PLD的曲线下面积,判断PLD的最优截断点并计算不同PLD水平的灵敏度、特异度、阳性预测值(PPV)、阴性预测值(NPV)、Youden指数。结果慢性乙型肝炎患者PLD值随着肝组织纤维化严重程度升高,各组之间比较差异有统计学意义(P<0.01)。ALT、AST、AST/ALT和PLD的ROC曲线下面积分别为0.600,0.642,0.662和0.794。PLD的最优截断点约为1 230 U/L,灵敏度和特异度分别为76.0%和74.4%。结论血清PLD测定对于慢性乙型肝炎患者肝组织纤维化程度判定有一定的临床价值。
Objective To study the relationship of prolidase （PLD） and liver fibrosis in chronic hepatitis B patients. Methods PLD activity in serum collected from 217 patients with hepatitis B were determined. To employ receiver operating characteristic curve （ROC） to evaluate diagnostic value of PLD activity. Results The AU- ROC of ALT,AST,AST/ALT and PLD was 0. 600,0. 642,0. 662 and 0. 794, respectively. The optimal cut-off value of PLD was 1230U/L. Sensitivity and specificity were 76.0% and 74.4% respectively. Conclusion PLD is a potent marker for assessing liver fibrosis stage in chronic hepatitis B patients.
基金
辽宁省教育厅2008年度高等学校科研项目(2008752)
