HIV母婴阻断抗病毒治疗线粒体毒性研究进展

Advanced research on mitochondrial toxicity from anti-retroviral therapy to prevent mother-to-child transmission

抗逆转录病毒治疗可明显降低HIV母婴传播率,但随之带来的药物相关线粒体毒副作用日渐增多,尽可能减少儿童因被动用药带来的器官功能障碍具有重要意义。本文就目前HIV母婴阻断抗病毒治疗对后代的影响进行了综述。

Anti retroviral therapy （ART） can significantly reduce mother-to-child transmission of HIV. However, mitochondrial toxicity caused by ART has become increasingly apparent, and a vital step is to reduce organ dysfunction due to drugs in infants as much as possible. The effect of ART on preventing mother-to-child transmission of HIV in off spring is reviewed.