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氟比洛芬酯联合丙泊酚用于胃镜检查术效果研究 被引量:1

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摘要 目的探讨氟比洛芬酯联合丙泊酚在胃镜检查术中麻醉及其术后镇痛的效果和安全性。方法将随机选择150例胃镜检查患者分为3组,每组均为50例。A组:注射生理盐水2 mL;B组:缓慢静脉注射芬太尼1μg/kg;C组:静脉注射氟比洛芬酯50 mg,3组均在10 min后静脉注射丙泊酚2 mg/kg,丙泊酚静注速率均为100mg/min。观察并纪录3组用药前、睫毛反射消失时、术中、术毕时的平均动脉压、心率、呼吸频率及右上肢末梢血氧饱和度,手术时间,苏醒时间,丙泊酚总用药量,不良反应,术中麻醉效果以及术毕清醒后1、5、15、30 min视觉模拟评分(VAS)值,并进行组间与组内比较。结果患者的睫毛反射消失时,C组的平均动脉压显著高于B组(P<0.05);睫毛反射消失时及术中呼吸频率及血氧饱和度C组显著高于B组(P<0.05),与A组差异无显著性(P>0.05)。术中麻醉效果评定为优、良、差的例数及术毕清醒后1、5、15、30 min时上腹部疼痛的VAS值,C组与B组比较差异无统计学意义;C组上腹痛疼痛程度明显减轻,与A组比较差异有显著性(P<0.05)。结论在胃镜检查术中应用氟比洛芬酯联合丙泊酚具有良好的术中麻醉及术后镇痛效果,对呼吸及循环抑制较轻,是一种安全有效的配伍方法。
出处 《广东医学》 CAS CSCD 北大核心 2010年第2期199-200,共2页 Guangdong Medical Journal
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