3例肾嫌色细胞癌的临床病理学特点报告并文献复习

Pathologic Features of Renal Chromophobe Cell Carcinoma （3 cases report and literature review）

【目的】探讨嫌色细胞癌的临床病理学特点。【方法】回顾性分析3例肾嫌色细胞癌患者的临床表现及病理学资料。【结果】3例患者均为女性，行肾癌根治术。术后病理诊断为肾嫌色细胞癌，免疫组织化学染色：Hale胶体铁染色均为阳性，Vimentin（波型蛋白）阴性，EMA阳性，CK7阳性，CK10染色阴性。【结论】肾嫌色细胞癌是一种低度恶性的肾细胞癌，影像学检查对其诊断有重要帮助，确诊有赖于组织病理学检查，手术治疗后预后较好。

[Objective]To investigate the pathologic features of renal chromophobe cell carcinoma（RCCC）. [Methods]The clinical manifestation and pathologic data of 3 cases with RCCC were analyzed retrospectively. [Results] Three cases with RCCC were female. They underwent radical nephrectomy. The pathological examination after operation confirmed the diagnosis of RCCC. lmmunohistochemical staining was performed. The staining for Hale＇s colloidal iron of tumor cells and the expression EMA and CK7 were positive. The expression of Vimentin and CK10 were negative. [Conclusion] RCCC is a distinct subtype of renal cell carcinoma that presents low-degree malignancy. The radiologic imaging plays an important role in diagnosis of RCCC. The definite diagnosis depends on histopathologic examination. The prognosis is more favorable than the other subtypes of renal cell carcinoma after operation.