膀胱移行细胞癌中淋巴管生长因子-D表达的研究

Research on the Expression of Vascular Endothelial Growth Factor-D in Bladder Transitional Cell Carcinoma

【目的]探讨淋巴管生长因子D（VEGF—D）在膀胱移行细胞癌（BTCC）中的表达情况与患者预后的关系。【方法】采用免疫组化研究50例BTCC中VEGFD蛋白表达的水平，评估VEGF-D表达与患者临床病理资料的相关性。【结论]50例中VEGF—D阳性表达率84．0％；VEGF-D阳性表达与肿瘤分级、分期及大小明显相关（P〈0．05）、与复发性无关（P〉0．05）。【结论】在BTCC中，VEGF-D表达水平明显增强且与病理分级、临床分期及肿瘤大小呈正相关，其可能成为诊断和判定预后的一个指标及一项新的治疗靶点。

[Objective]To investigate the expression and clinical significance of vascular endothelial growth factor-D（VEGF-D） in bladder transitional cell carcinoma（BTCC）. [Methods] The expression of VEGF-D in 50 BTCC was detected by immunohistochemistry. The relationship between VEGF-D expression and clinico pathological parameters was assessed. [Results]VEGF D expression was identified in 42 cases （84%）. Higher expression of VEGF-D was significantly correlated with poor histological grade, clinical stage and tumor size （ P〈0.05）, but not related with relapse（ P〉0. 05）. [Conclusion]There is positive correlation between the increased expression of VEGF and pathological grade, clinical stage and tumor size of patients with BTCC. It may be a novel biomarker and treatment target for the diagnosis and prognosis of BTCC.