奥美拉唑联合黛力新治疗非糜烂性胃食管反流病疗效观察

Clinical Efficacy of Omeprazole in Combination with Deanxit for the Treatment of Non-Erosive Gastroesophageal Reflux Disease

【目的】探讨质子泵抑制剂奥美拉唑联合黛力新治疗非糜烂性胃食管反流病（NERD）的临床疗效。【方法】将本院2008年1月至2008年12月消化门诊及住院共82例NERD患者随机分为两组，A组41例，给予奥美拉唑20mg，早、晚餐前各1次，黛力新10．5mg，早、中餐后各1次；B组41例，给予奥美拉唑20mg，早、晚餐前各1次，两组疗程均为6周，疗程结束后通过症状记分，判断疗效。【结果】治疗6周后，A组显效率为73．17％，总有效率为93．68％；B组显效率为41．46％，总有效率为75．61％。两组比较差异有显著性（P〈0．05）。【结论】奥美拉唑联合黛力新是治疗伴有抑郁和（或）焦虑的NERD患者的有效方案。

[Objective]To study the clinical efficacy of Omeprazole in combination with Deanxit in treating patients with non-erosive gastroesophageal reflux disease. [Methods]Eighty two patients with non-erosive gas troesophageal reflux disease were randomly divided into two groups. Forty one patients （Group A） received Omeprazole （20mg） bid before breakfast and supper respectively plus Deanxit（10.5mg） bid after breakfast and lunch respectively. Forty one patients （Group B） received Omeprazole （20mg） bid before breakfast and lunch respectively. After treatment for 6 weeks, the therapeutic efficacy in the two groups was evaluated based on the symptom scores. [Results]There were significant differences between the two groups on total effective rate （93.68% in Group A vs. 75. 61% in Group B） （ P 〈0. 05）. [Conclusion]Omeprazole in combination with Deanxit is an effective treatment for patients with non-erosive gastroesophageal reflux disease.