大鼠口服低分子肝素的绝对生物利用度测定

Determination of Absolute Bioavailability of Rats after Oral Low Molecular Weight Heparin

运用柱层析、比色技术测定了大鼠口服及静脉注射低分子肝素后的血浆药物浓度—时间曲线，并以梯形法求算出大鼠口服低分子肝素的绝对生物利用度。结果表明，低分子肝素口服后可快速进入体内，绝对生物利用度为89．9％，为低分子肝素口服制剂的研究提供了重要的依据。

On the basis of its chemical nature as anionic polyelectrolytes and for the first time, thedrug concentration of low molecular weight heparin (LMWH ) in plasma vs. time curve wasdetermined after oral administration and iv injection in ratS, and the absolute bioavailability was alsocalculated by ladder-shaped method. The results show that LMWH can quickly incorporate into bodywhen administered orally, and its absolute bioavailability reached 89. 9%. This provides significantbasis for research of LMWH oral preparation.