玻璃酸钠关节腔内注射治疗膝骨关节炎

Treatment of Osteoarthritic Knee Joint with Sodium Hyaluronate Injected Intra-articularly

对30例骨关节炎（OA）患者的30个膝关节腔内注射1％玻璃酸钠（SH）注射液，观察其疗效及维持时间。每周给药1次，每次2ml，连续给药5周。给药5周后考察步行能力、日常动作、疼痛、肿胀等临床症状的改善情况以判定药物的疗效，实验室检查血、尿以考察安全性。停止治疗的16个月内对疗效进行追踪考察。结果表明，治疗5周后，患者除关节积液外各项临床症状均获得显著性改善，总有效率为96．7％，未见明显的毒副反应。停药16个月，70．0％患者症状未复发。结果提示，SH可能为治疗膝OA的有效药物。

30 patients (30 knees) with osteoarthritis were treated with 2 ml of 1 % SH injected intra-articularly for five times at one week intervals. Walking ability, normal activity' joint pain, swellingand exudate were the indexes examined to evaluate the efficacy, and urinary and blood samples weredetected to evaluate the safety. 96. 7% of the patients got shoificant improvement in those indexesafter 5 weeks treatment. The symptoms of 70. 0% patients did't recur within 16 month duration. Theresult indicated SH may be valuable in oA treatment.