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血清丙二醛、总抗氧化能力、维生素E与糖尿病下肢血管病变的关系 被引量:3

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摘要 目的:分析血清丙二醛、总抗氧化能力、维生素E与糖尿病下肢血管病变的关系。方法:选取75例2型糖尿病合并下肢血管病变患者(DM1组)与40例单纯糖尿病患者(DM2组)及35例正常健康对照组(NC组)的血清丙二醛(MDA)、总抗氧化能力(TAOC)、维生素E(VE)。结果:MDA在DM1组(8.03±4.99)高于DM2组(7.32±2.80)和NC组(4.08±0.74),均有统计学差异(P<0.05)。总抗氧化能力、维生素E在DM1组(8.15±10.53、5.54±1.77)低于DM2组(9.27±3.17、6.26±1.14)和NC组(11.32±3.25、7.04±2.49),均有统计学差异(P<0.05)。结论:糖尿病氧化应激状态增强,抗氧化状态减弱,糖尿病合并下肢血管病变时更为明显。
作者 高利娟
出处 《中国误诊学杂志》 CAS 2010年第4期774-775,共2页 Chinese Journal of Misdiagnostics
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参考文献6

  • 1Sima A, Sugimoto K. Experimental diabetic neuropathy: an update[J]. Diabetologia,1999,42(3):773-788.
  • 2Ono Y, Aoki S, Ohnishi K; et al. Increased serum levels of advanced glycation end products in NIDDM patients with diabetic complica-tions[J]. Diabetes Care,1998,21(2):1021-1027.
  • 3Benesch KG. On a possible mechanism of action of ascorbie acid:formation of ionic bonds with biological molecules[J]. Biochem Biophys Res Comm, 1981,101(5):312-316.
  • 4Brownlee M,Cerami A, Vlassara H. Advanced glycosylation end products in tissues and the biochemic basis of diabetic complication[J]. N Eng J Med,1988,318(9525) :1315-1321.
  • 5Ceriello A, Giugliano D, Quatraro A, et al. Vitamin E reduction of protein glycosylation in diabetics: new prospect for prevention of diabetic complication[J]. Diabetes Care, 1991,14(5) : 68-72.
  • 6毛晓明,刘志民,石勇栓,蒋克春,王爱萍,饶亚平.维生素E与维生素C联合治疗对糖耐量受损患者糖代谢的影响[J].中华糖尿病杂志(1006-6187),2004,12(6):413-416. 被引量:12

二级参考文献10

  • 1Haffner SM, Miettinen H, Stern MP. The homeostasis model in the San Antonio Heart study. Diabetes Care, 1997, 20:1087-1092.
  • 2Konukoglu D, Hatemi H, Ozer EM, et al. The erythrocyte glutathione levels during oral glucose tolerance test. J Endocrinol Invest, 1997, 20:471-475.
  • 3Opara EC. Role of oxidative stress in the etiology of type 2 diabetes and the effect of antioxidant supplementation on glycemic control. J Inwestig Med, 2004,52:19-23.
  • 4De Mattia G, Bravi MC, Laurenti M, et al. Influence of reduced glutathione infusion on glucose metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism, 1998, 47: 993-997.
  • 5Yanagawa K, Takeda H, Egashira T, et al. Changes in antioxidative mechanisms in elderly patients with non-insulin-dependent diabetes mellitus: Investigation of the redox dynamics of alpha-tocopherol in erythrocyte membranes. Gerontology, 2001, 47: 150-157
  • 6Jain SK, McVie R, Smith T. Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic children. Diabetes Care, 2000, 23: 1389-1394.
  • 7Sargeant LA, Wareham NJ, Bingham S, et al. Vitamin C and hyperglycemia in the European Prospective Investigation into Cancer--Norfolk (EPIC-Norfolk) study: a population-based study. Diabetes Care, 2000, 23: 726-732.
  • 8Montonen J, Knekt P, Jarvinen, R et al. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care, 2004,27:362-366.
  • 9Paolisso G, D'Amore A, Giugliano D, et al. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients.Am J Clin Nutr, 1993, 57: 650-656.
  • 10Paolisso G, D'Amore A, Balbi V, et al. Plasma vitamin C affects glucose homeostasis in healthy subjects and in non-insulin-dependent diabetics.Am J Physiol, 1994, 266: E261-E268.

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