表皮生长因子受体和血管内皮生长因子在非小细胞肺癌中的表达及意义

Expression and clinical significance of epidermal growth factor receptor and vascular endothelial growth factor in non-small cell lung cancer

目的观察非小细胞肺癌(NSCLC)组织中表皮生长因子受体(EGFR)和血管内皮生长因子(VEGF)的表达情况以及与临床病理参数的关系。方法免疫组织化学法检测76例NSCLC组织和14例非恶性肺组织EGFR和VEGF的表达。结果EGFR和VEGF在76例NSCLC组织中的阳性表达率分别为47.4%(36/76)和51.3%(39/76),在14例非恶性肺组织表达率分别为7.14%(1/14)和7.14%(1/14),两组EGFR、VEGF表达差异显著(P<0.05)。Ⅲ期NSCLC组织的EGFR表达率为56.8%(25/19),高于Ⅰ～Ⅱ期患者的31.3%(10/32),两者差异显著(P<0.05),EGFR表达与其他临床病理参数均无关;淋巴结阳性的NSCLC组织VEGF表达率为77.8%(28/34),明显高于淋巴结阴性的27.5%(11/42),两者差异显著(P=0.000),VEGF表达与肿瘤分期、性别、年龄、肿瘤细胞分化等临床病理参数亦无关。EGFR和VEGF在NSCLC组织中表达无相关性(P>0.05)。结论NSCLC组织中EGFR和VEGF常常为高表达,EGFR表达与肿瘤的TNM分期有关,VEGF与淋巴结转移有关;但是EGFR和VEGF的表达之间无相关性。

Objective To observe the expression of epidermal growth factor receptor（EGFR） and vascular endothelial growth factor（VEGF） in non-small cell lung cancer（NSCLC） and correlated with clinicopathologic parameters. Methods HE staining of paraffin sections was used to study lymph node metastatic status. Immunohistoehemistry of tissue sections was used to study the expression of EGFR and VEGF in seventy-six NSCLC tissues and 14 cases of normal lung samples. Results The positive rates of EGFR and VEGF in 76 NSCLC samples were obviously higher than those in the 14 normal lung samples（47.4% vs. 7.14% for EGFR, 51.3% vs. 7. 14% for VEGF, P 〈0. 05）. The positive rate of EGFR with stage Ⅲ was higher than that with stage Ⅰ/Ⅱ（56. 8% vs. 31.3% , P 〈 0. 05 ）. The positive rate of VEGF with lymph node metastasis was higher than that without lymph node metastasis （ 77.8% vs. 27.5% ,P = 0. 000）. EGFR and VEGF expression was not statistically correlated with each other. Conclusion EGFR and VEGF were overexpressed in NSCLC tissues. The expression of EGFR in NSCLC was correlated with TNM stages. The expression of VEGF in NSCLC was correlated with lymph node metastasis. The expression of EGFR was not correlated with VEGF expression in NSCLC tissues.