摘要
目的回顾分析经免疫组化检测ER-、PR-和HER-2-乳腺癌(三阴性乳腺癌)的临床资料,探讨其临床特点和生存情况。方法回顾分析我院2001年1月～2004年3月诊治的41例三阴性乳腺癌患者的发病年龄、肿瘤大小、淋巴结转移情况、术后辅助治疗、肿瘤复发及生存情况。结果41例三阴性乳腺癌病例中,中位发病年龄49岁,43.6%的患者首诊时伴有淋巴结转移;可随访的35例病例中,27例接受了术后辅助治疗。中位随访时间5年,1、3、5年生存率分别为100.0%、74.0%和57.0%,20例出现了肿瘤复发和转移,内脏转移40.0%,软组织转移20.0%,骨转移6.0%。结论三阴性乳腺癌首诊时淋巴结转移率高,复发后内脏及软组织转移率高,生存时间较短。
Objective To investigate triple negative breast cancer（TNBC） patients＇ clinical manifestation and their survival. Methods To evaluate 41 cases with TNBC treated in our hospital from January 2001 to March 2004, including age at diagnosis, size of mass, lymph node involvement, adjuvant therapy, recurrence of disease and survival of patients. Results Median age of 41 cases was 49, 46. 3% of patients had lymph nodes involvement at diagnosis. Thirty-five patients were followed and twenty-seven had adjuvant therapy. Median follow-up time was 5 years, 1-, 3- and 5- year survival rate was 100. 0% ,74. 0% and 57.0% respectively. Twenty cases developed tumor recurrence and metastasis which included 40. 0% of visceral metastasis, 20. 0% of soft tissue recurrence and 6.0% of bone metastasis. Conclusion TNBC showed higher lymph nodes involvement at diagnosis, more visceral and soft tissue metastasis after disease recurrence and poor survival.
出处
《临床肿瘤学杂志》
CAS
2010年第1期52-54,共3页
Chinese Clinical Oncology
关键词
三阴性乳腺癌
临床特点
生存分析
Triple negative breast cancer（TNBC）
Clinical features
Survival analysis
