816株真菌感染分布及药敏分析

Distribution and Antibiotic Resistance Analysis of 816 Fungal Isolates from Our Hospital

目的了解本院医院感染真菌分布的特点及对常用抗真菌药物的耐药情况。方法CHROMagar显色培养基及ATB真菌试剂盒进行鉴定;药敏试验采用纸片扩散K-B法。结果2008年1月至2009年6月我院临床共分离真菌816株,其中白色念珠菌(占53.2%)是引起真菌感染的最常见菌种,其次是热带念珠菌(21.6%)、光滑念珠菌(15.6%)、近平滑念珠菌(5.0%)和克柔念珠菌(2.3%)。药敏试验结果显示各种真菌对两性霉素B、制霉菌素的敏感性最高,分别达98%和99%,其次是氟康唑、伊曲康唑。结论真菌感染率呈逐年上升趋势,耐药率也逐渐增高。因此应及时对送检标本进行真菌培养和药敏试验,合理使用抗真菌药物,减少医院感染多重耐药和深部真菌感染的发生。

Objective To study the distribution and antibiotic resistance of fungal isolates from our hospital. Methods The fungal isolates and distribution were identified by CHROMagar medium and ATB fungus kits. Results A total of 816 fungi were isolated from January 2008 to June 2009. C.albicans was the most prevalent fungus （53.2%）, followed by C.tropicalis （21.6%）, and C.glabrata（15.6%）, accounted for most of clinical fungal infections. Amphotericin B and nystatin were effective for the treatment of fungal infections due to their good in vitro effect. Conclusion Nosocomial fungal infections and resistance of antibiotic were increasing every year. Fungal isolation, identification and efficacy monitoring are very important to guide clinical rational drug using.