晚期肝癌患者血清左旋卡尼汀水平与恶病质相关性的分析

Correlation between serum L-carnitine and cachexia in patients with advanced liver cancer

目的观察晚期肝癌患者血清左旋卡尼汀(LC)水平的变化及其与肿瘤恶病质的相关性。方法以30例健康正常人为对照,采用串联质谱法检测42例晚期肝癌患者血清LC水平,全自动生化仪检测血清生化指标,ELISA方法检测血清TNF-α、IL-6、瘦素水平,并测体重指数(BMI)和肿瘤生活质量KPS、QOL评分。结果与正常对照相比,肝癌患者血清LC显著下降,且与血清TNF、IL-6呈负相关,与瘦素、前白蛋白、白蛋白呈正相关,与BMI、KPS、QOL评分呈正相关。结论血清LC水平降低与肝癌晚期恶病质的发生关系密切,可能成为肿瘤恶病质发生机制及治疗研究的新靶点。

Objective To observe the correlation between serum L-carnitine（LC） and cachexia in patients with advanced liver cancer.Methods Forty-two patients with advanced liver cancer were used as the study group,and 30 healthy people were used as controls.Serum LC level was determined by tandem mass spectrometry.Serum biochemical variables were measured.The levels of serum TNF-α,IL-6 and leptin were measured by ELISA.BMI,KPS score and QOL score were also calculated.Results Compared to the controls,the levels of LC significantly decreased in patients with advanced liver cancer.The serum LC level had the significant negative correlation with TNF-α and IL-6.The serum LC level had the significant positive correlation with leptin,prealbumin,albumin,BMI,KPS score and QOL score.Conclusion The results indicate that decreased serum LC level is closely associated with the development of cachexia in patients with advanced liver cancer,and this correlation may prove to be a new target for the study of pathogenesis and treatment of cancer cachexia.