顶空气相色谱法测定化妆品中15种挥发性有机溶剂残留

Determination of 15 volatile organic compound residues in cosmetics by headspace gas chromatography

建立了化妆品中15种挥发性有机溶剂残留的顶空气相色谱测定方法。样品经60℃、30min静态顶空后,采用气相色谱-氢火焰离子化检测器进行检测,外标法定量。加标回收试验结果表明:15种挥发性有机溶剂残留平均回收率为62.8%～116%,相对标准偏差均小于5%。方法的检出限为0.09～0.68mg/kg。该方法可有效克服基体干扰,一次进样可同时分离和测定化妆品中15种挥发性有机溶剂,准确灵敏,简单快速,适用于化妆品中挥发性有机溶剂残留的检测。

A headspace gas chromatography （HS-GC） method was developed for the rapid determination of multi-mixture of 15 residual volatile organic compounds in cosmetics. The experimental conditions of HS-GC such as headspace temperature, headspace time and the analytical conditions of GC were optimized. Cosmetic samples were extracted and cleaned-up by headspace at 60 ℃ for 30 min, determined by GC-flame ionization detector （FID） and quantified by external standard method. The 15 poisonous volatile organic compounds were separated efficiently from impurities with high sensitivity and reproducibility. The relative standard deviations （RSDs） were less than 5%, the recoveries were from 62.8%-116%, the linear range was 0.002-2.0 mg/L with a good linear correlation coefficient （r0.999） and the limits of detection were 0.09-0.68 mg/kg. By means of the above developed HS-GC method, 15 residual volatile organic compounds in cosmetics were detected accurately and simultaneously in a single sample injection. The method is accurate, simple, rapid, and is suitable for the trace analysis of multi-mixture of residual volatile organic compounds in various cosmetics.