期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Ki67在乳腺癌组织中表达及其与C-erbB-2、ER、PR、P53基因的关系 被引量：12

The expression of Ki67 in the breast cancer tissue and its correlation with C-erbB-2、ER、PR and P53
下载PDF
导出
摘要 目的:探讨Ki67基因在乳腺癌组织中的表达及其与C-erbB-2、ER、PR、P53基因的相关关系。方法:用免疫组化方法检测133例乳腺癌组织中Ki67、C-erbB-2、ER、PR、P53的表达。结果:Ki67在乳腺癌组织中总阳性率为78.2%,Ki67表达与乳腺癌肿瘤大小和临床分期有显著相关性(P<0.05),与患者的年龄、腋窝淋巴结转移无显著相关性(P>0.05);乳腺癌组织的Ki67表达强度与C-erbB-2、P53强度的表达呈正相关(γ分别为0.172、0.280,P<0.05),与ER强度的表达呈负相关(γ为-0.193,P<0.05),与PR表达强度无显著相关性(γ为-0.007,P>0.05)。结论:Ki67表达与乳腺癌发生、发展有关,是一个不良预后因素。 Objective：To investigate the expression of Ki67 in the breast cancer tissue and its correlation with C - erbB - 2, ER,PR and P53. Methods：The expression of Ki67, C -erbB -2, ER,PR and P53 in 133 cases of breast cancer were assessed by immunohistochemistry. Results： The result indicates that the total positive rate of Ki67 in breast cancer issue is 78.2%. The expression of Ki67 has significant correlation with tumor size and clinical stages（ P 〈 0.05 ） , but not with the patients＇age or axillary lymph node metastasis（P 〉0.05）. The expression strength of Ki67 has positive correlation with that of C -erbB -2 and P53 （γ0. 172 and 0.280 respectively, P 〈 0.05 ） , and it negatively correlates with the expression strength of ER（ γ-0. 193, P 〈 0.05 ）. And there is no significant correlation between the expression strength of Ki67 and that of PR （ γ - 0.007, P 〉 0.05）. Conclusions ： The expression of ki67 is related with the occurrence and progression of breast cancer. And it can determine the progrosis of breast cancer.
作者 朴正日 金全金 申龙河
机构地区 吉林省延吉市延边肿瘤医院外科 吉林省延边大学附属医院普通外科
出处 《中国民康医学》 2010年第3期258-260,265,共4页 Medical Journal of Chinese People’s Health
关键词 乳腺癌 KI67 C—erbB-2 ER PR P53 免疫组化 Breast cancer Ki67 C - erbB - 2 ER PR P53 Immunohistochemistry
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献11

  • 1Tan PH, Bay BH, YipG, et al. Lmmunohistochemical detection of Ki67 in breast cancer correlates with transcriptional regulation of genes related to apoptosis and cell death [ J ]. Mod Pathol,2005,18 (3) :374 -381.
  • 2Gerdes J, Lemke H, Baisch H, et al. Cell cycle analysis of a cell proliferation associated human nuclear antigen defined by the monoelonal antibody Ki67 [ J ]. J Immunol, 1984, 133 ( 13 ) : 1710 - 1715.
  • 3Tut VM, Braithwaite AL, Angus B, et al. Cyclin D1 expression in ransitional cell carcinoma of the bladder: correlation with p53, wafl,pRb and Ki67[J]. Br J Cancer,2001,84(2) :270 -275.
  • 4Liu M, Lawson G, Delos M, et al. Predictive valus of the fraction of cancer cells immunolabeled for proliferating cell nuclear antigen or Ki67 in biopsies of head and neck carcinomas to identify lymph node metastasis:comparison with clinical and radiologic examinations[ J]. Head Neck,2003,25 (4) :2S0 - 2SS.
  • 5Repana K, Papazisis K, Foukas P, et al. Expression of Syk in invasive breast cancer: correlation to proliferation and invasiveness [ J]. Anticancer Res, 2006,26 ( 6 C ) : 4949 - 4954.
  • 6Bhatavdekar JM,Patel DD, Shah NG, et al. Prognostic significance of immunohisto - chemically localized biomarkers in stage Ⅱand stage Ⅲ breast cancer:a multivariate analysis [ J ]. Ann Surg Oncol,2000,7(4) :305 -311.
  • 7李宝江,朱志华,王军业,侯景辉,赵进明,张蓬原,姚广裕,王曦,龙浩,杨名添,戎铁.Ki67、P53、VEGF和C-erbB-2在乳腺癌组织中表达的相关性研究及其临床意义[J].癌症,2004,23(10):1176-1179. 被引量：126
  • 8Volpi A, Nannl O, De paola F. HER- 2 expression and cell proliferation : prognostic markers in patients with node - negative breast cancer[ J]. J Clin Oncol,2003,21 (14) :2708 -2712.
  • 9Rohan TE, Li SQ, Hartwick R, et al. p53 alterations and protein accumulation in benign breast tissue and breast cancer risk : a cohort study [ J ]. Cancer Epidemiol Biomarkers Prev, 2006,15 ( 7 ) : 1316 - 1323.
  • 10李菊英.Cerb-B2、P^(53)、ER、PR在乳腺癌中的表达和预后[J].青海医学院学报,2004,25(1):26-28. 被引量：27

二级参考文献18

  • 1Gerdes J, Schwab U, Lemke H, et al. Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation [J]. Iht J Cancer, 1983,31 (1):13-20.
  • 2Hall PA, Levison DA, Woods AL, et al. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms [J]. J Pathol, 1990, 162(4): 285-294.
  • 3Mullerat J, Deroide F, Winslet MC, et al. Proliferation and p53expression in anal cancer precursor lesions [J]. Anticancer Res,2003, 23 (3C): 2995-2999.
  • 4Liu M, Lawson G, Delos M, et al. Predictive value of the fraction of cancer cells immunolabeled for proliferating cell nuclear antigen or Ki67 in biopsies of head and neck carcinomas to identify lymph node metastasis: comparison with clinical and radiologic examinations [J]. Head Neck,2003,25(4): 280-288.
  • 5Tut VM, Braithwaite AL, Angus B, et al. Gyclin D1 expression in transitional cell carcinoma of the bladder: correlation with p53,wafl, pRb and Ki67 [J]. Br J Gancer,2001, 84(2): 270-275.
  • 6Bhatavdekar JM, Patel DD, Shah NG,et al. Prognostic significance of immunohisto-chemically localized biomarkers in stage Ⅱ and stage Ⅲ breast cancer: a multivariate analysis [J] . Ann Surg Oncol,2000, 7 (4): 305-311.
  • 7Vincent-Salomon A, Rousseau A, Jouve M, et al. Proliferation markers predictive of the pathological response and disease outcome of patients with breast carcinomas treated by anthracycline-based preoperative chemotherapy [J]. Eur J Cancer,2004(40): 1502-1508.
  • 8Nakopoulou L, Stefanaki K, Panayotopoulou E, et al. Expression of the vascular endothelial growth factor receptor-2/Flk-1 in breast carcinomas: correlation with proliferation [J]. Hum Pathol,2002,33(9): 863-870.
  • 9Norberg T, Klaar S, Kaff G, et al. Increased p53 nutation frequency during tumor progression-results from a breast cancer cohort [J]. Cancer Res, 2001, 61 (22): 8317-8321.
  • 10Davidoff AM, HerndonJE, Glover NS, et al. Relation between p53overoxpression and established prognostic factors in breast cancer [J]. Surgery, 1991, 110(2): 259-264.

共引文献151

同被引文献152

引证文献12

二级引证文献65

中国民康医学
2010年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部