早发型重度子痫前期的临床特点和妊娠结局分析

Clinical features and pregnancy outcomes of early-onset severe pre-eclampsia.

目的探讨早发型重度子痫前期的临床特点及围产结局。方法回顾性分析2004年11月至2009年2月东南大学附属中大医院妇产科分娩的96例重度子痫前期患者的临床资料，将其分为早发型重度子痫前期组（早发型组，妊娠〈34周）和晚发型重度予痫前期组（晚发型组，妊娠≥34周）。结果与晚发型组相比，早发型组在中枢神经系统症状、蛋白尿（＋＋）或〉2g／24h方面、畀常围生儿结局的发生率方面差异均有统计学意义（X^2值分别为14．792、4．741、27．03，P均〈0．05）。早发型组围生儿的平均出生体重（1743．86±630．34）g明显低于晚发型组（2940．47±762．36）g（t=6．71，P〈0．05）。结论早发型重度子痫前期患者的病情重，异常围产儿结局发生率高，存活率低。积极预防、预测、早期诊断及处理早发型重度子痫前期患暑奸改善毋皿而后意义量女．

Objective To explore clinical features and pregnancy outcomes of early-onset severe preeclampsia. Methods Clinical data of 96 cases of severe preeclampsia who deliveried in Southeast University from November 2004 to February 2009 were analyzed. The patients were divided into two groups, early-onset preeclampsia group（ onset gestational weeks 〈 34 ） and later-onset preeclampsia group （onset gestational weeks≥34 ）. Results Significant difference of two groups were found in central nervous system symptom and urine protein （ ＋ ＋ ） or 〉 2 g/24 h （ P 〈 0.05 ）, incidence of abnormal prenatal outcome （ X^2 = 14.792,4. 741,27.03 respectively; P 〈 0.05 ）. Mean birth weight in early-onset preeclampsia group （ 1743.86±630.34 ） g was lower than that in later-onset preeclampsia group （2940.47±762.36） g （ t = 6.71, P 〈 0.05 ）. Conclusions Clinical symptoms of early-onset severe preeclampsia are severe , and have a higher incidence of abnormal prenatal outcomes. Prevention, prediction, diagnosis and management of preeclampsia are important for mothers and children.