奥氮平与氯氮平治疗康复期精神分裂症的对照研究

Comparison study in the treatment on recovery of schizophrenic patients between olanzapine and clozapine

目的:比较奥氮平与氯氮平治疗康复期精神分裂症患者的临床疗效与安全性。方法:将康复期精神分裂症患者100例随机分为奥氮平组与氯氮平组,疗程12周,采用阳性与阴性症状量表(PANSS)及治疗中出现的症状量表(TESS)、健康状况问卷(SF-36)评定疗效及不良反应。结果:两组治疗后PANSS评分均显著下降,两组间比较差异无显著性(P>0.05)。不良反应发生率奥氮平组显著低于氯氮平组(P<0.05)。结论:奥氮平治疗康复期精神分裂症患者的疗效与氯氮平相仿,不良反应少,是一种安全有效的抗精神病药。

Objective：To compare the clinical efficacy and safety between olanzapine and clozapine in the treatment on recovery of schizophrenic patients. Methods： 100 patients with recovery of schizophrenic patients were randomly divided into two groups, olanzapine group and clozapine group for 12 weeks. Positive and negative symptom scale （PANSS）, treatment emergent symptom scale （TESS）, and short form 36 health survey questionnaire （SF -36） were used to evaluate the efficacy or safety. Results： The total scores of PANSS obviously decreased in both groups and there was no significant difference between the two groups after treatment （P 〉 0.05 ）. The incidence rate of side effects in olanzapine group was significant lower than that in clozapine group （P 〈 0.05 ）. Conclusions ： olanzapine is a safe and effective antipsy - chotic drug, with similar efficacy as clozapine and fewer side effects in the treatment on recovery of schizophrenic patients.