利培酮治疗55例老年期精神障碍临床观察

Clinical Analysis of Risperidone in Treatment of the Senile Psychiatric Patients

目的：探讨利培酮治疗老年期精神障碍的疗效与不良反应。方法：55例老年期精神障碍服用利培酮治疗6周以上，治疗量为每日2～4mg。用BPRS及TESS进行评分，然后进行统计学分析。结果：利培酮治疗老年期精神障碍，治疗前与治疗后BPRS五个因子分治疗有显著性差异，其中因子2与因子3减分幅度较明显。总有效率为85．45％。锥体外系反应是利培酮较常见的不良反应，其发生率为25．5％。结论：利培酮不仅可以治疗精神分裂症，而且还可以治疗老年期精神障碍。它疗效佳、剂量低、不良反应小、服用方便、耐受性好，可以作老年精神障碍的首选药物。

Objective：To discuss the therapeutic and side effects of Risperidone in treatment of the senile psychiatric patients. Methods ：55 senile psychiatric patients were treated with Risperidone more than 6 weeks. The therapeutic and side effects were evaluated with BPRS and TESS respectively. Results ： There were significant differences in scores of the 5 factors of BPRS after treatment, of which scores of the factor 2 and 3 decreased more rapidly. The total effective rate was 85.54%. EPS were the most common side effects of risperidone, they occurred in 25.5% of the subjects. Conclusions： Risperidone can be used in treatment not only in schizophrenic patients but also in senile psychiatric patients, and it could be the choice drug in senile psychiatric patients because of its excellent therapeutic effect, lower dosage, fewer side effects and better tolerance.