肝泰乐生产废液常压下水解制备乙酰丙酸

Acid hydrolysis experimental studies for levulinic acid production from glucurolactone waste liquid at atmospheric pressure

以肝泰乐废液为原料制备乙酰丙酸,并对制备工艺进行优化,得出了废液在酸性条件下回流水解,浓缩,乙醚萃取,活性炭脱色重结晶制备乙酰丙酸的工艺.通过正交实验优化,最佳工艺条件为:废液与水的质量比是0.3,浓盐酸与水的质量比是0.4,600 r/min搅拌下,加热回流15 h.为肝泰乐生产企业提供了一条综合利用,变废为宝的有效途径.

Glucurolactone is an effective drug for protecting liver. However, the processes of glucurolactone prepared from starch bring a mass of waste liquid at the same time, which pollute the environment seriously. The method, to produce levulinic acid from glucurolactone waste liquid, was studied and optimized for the technologic condition. The results show that levulinie acid can be obtained through hydrolyze the waste liquid aroused from producting process of glucurolactone under acid condition, followed concentration, extraction with ether and decoloration by activated carbon and recrystallization. The orthogonal test indicates that the best condition is as follows： the mass ratio of waste liquid, concentrated hydrochloric acid and water is 3 ： 4 ： 10, at stirring under 600 r/min and heating to reflux for 15 h. The study provides a comprehensive use of waste as an effective way to glucurolactone manufacturers.