吸烟对血液过氧化与抗氧化平衡的影响

Effects of cigarette smoking on oxidative and antioxidative balance of human blood

比较吸烟与不吸烟人静脉血血浆及红细胞脂质过氧化物-丙二醛（MDA）含量，血浆及红细胞超氧化物歧化酶（SOD）活力、全血谷胱甘肽过氧化物酶（GSH－Px）活力及血浆总抗氧化能力（AOA）．结果表明：吸烟组血浆及红细胞MDA的含量高于不吸烟组（P＜0．01），红细胞SOD含量高于不吸烟组（P＜0．01），血浆SOD、全血GSH－Px活力．血浆AOA均低0于不吸烟组（P＜0．01，P＜0．05，P＜0.05）．提示长期吸烟可使血中氧化与抗氧化失去平衡。

The MDA levels in erythrocyte and plasma, the SOD activity in erythrocyte and plasma, the blood GSH-Px activity and the AOA were compared in smokers and non-smokers. It was found that erythrocyte MDA level, plasma MDA and ewtrocyte SOD of smokers were significantly higher than those of the non-smokers (P<0.01). Plasma SOD, blood GSH-Px and plasma AOA of smokers were lower than those of the non-smokers (P<0.01, P<0.05, P<0.05). These results suggest that cigarette smoking might cause an imbalancc between oxidation and antioxidation in blood.