喹硫平治疗老年痴呆精神行为症状的对照研究

Control Study on Quetiapine Treating Behavioral and Psychological Symptoms of Dementia in Old Ages

目的观察喹硫平和氟哌啶醇治疗老年痴呆精神行为症状的疗效和安全性。方法采用随机对照研究,喹硫平组36例,剂量(140±50)mg/d,氟哌啶醇组33例,剂量(4.5±1.5)mg/d,疗程12周,治疗前后采用痴呆病理分析评定量表(BEHAVE-AD)、Cohen-Mansfied激越问卷(CMAI)评定疗效,用副反应量表(TESS)评定不良反应。结果两组病人治疗后BEHAVE-AD评分显著下降(P<0.01),两组病人之间治疗前后BEHAVE-AD的减分值无显著差异(P>0.05),氟哌啶醇组38%有锥体外系反应,明显高于喹硫平组的3%,并有显著差异(P<0.05)。结论喹硫平和氟哌啶醇治疗老年痴呆精神行为症状疗效确切,喹硫平不良反应少。

Objective To assess the effeet and safety of quetiapine and haloperidol in the treatment of behavioral and psychological symptoms of dementia （BPSD）. Methods A randomized comparative study was carried out for 36 patients of quetiapine group whieh were treated with quetiapine （140± 50）mg/d; and 33 patients of haloperidol group received haloperidol （4.5±1.5）mg/d; with a eourse of 12 weeks. BEHAVE--AD, CMAI were used for the pathogenesis analysis of denmentia before and after treatment. Results After 12 weeks＇ treatment, the scores of BEHAVE--AD of patients in both groups significantly redueed （P〈0. 01 ）, but there were no significant differenee between the two groups （P〈0.05）. The incidence of EPS was 3% in quetiapine group, which was significantly Iower than 38% in haloperidol group （P-〈0.05）. Conclusion Quetiapine and haloperidol slow good effect for treating BPSD. Quetiapine is better with less adverse reaction.